Long non-coding RNA CDKN2B-AS1 regulates high glucose-induced human mesangial cell injury via regulating the miR-15b-5p/WNT2B axis

Abstract Background Long non-coding RNA cyclin-dependent kinase inhibitor 2B antisense Roof Rack RNA 1 (CDKN2B-AS1) has been reported to be related to diabetic nephropathy (DN) progression.However, the regulatory mechanisms of CDKN2B-AS1 in DN are unclear.Methods High glucose (HG) was used to induce human mesangial cells (HMCs) for establishing the

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Characterization of a hypervirulent multidrug-resistant ST23 Klebsiella pneumoniae carrying a blaCTX-M-24 IncFII plasmid and a pK2044-like plasmid

Objective: To Seasonal Easter characterise a multidrug-resistant hypervirulent Klebsiella pneumoniae (MDR-hvKp) strain (Kpn1693) isolated from the sputum of a 67-year-old male patient diagnosed as having bronchiectasis with infection in Northern China.Methods: Drug susceptibility testing was performed by broth microdilution method, and the hypervir

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